Methods and compositions for modulating lymphangiogenesis, e.g., to treat transplant rejection, in a subject
AssigneeThe Regents of the University of California
InventorLu Chen
Life of this patent
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Abstract
Methods of modulating the occurrence of lymphangiogenesis in a subject are provided. In some instances, the method is a method of treating transplant rejection in the subject. Aspects of the methods include administering to the subject an effective amount of: a first antagonist for a tyrosine kinase receptor and a second antagonist for an integrin receptor. In some embodiments, the methods include enhancing survival of transplanted tissue in a subject. Aspects of the invention further include compositions, e.g., pharmaceutical compositions and kits that find use in methods of the invention.
Claims24
A method of modulating the occurrence of lymphangiogenesis in a subject, the method comprising:
- administering to the subject an amount of:
- a first antagonist for a tyrosine kinase receptor;
- and
- a second antagonist for an integrin receptor;
- effective to modulate the occurrence of lymphangionesesis in the subject.
4-7. (canceled)
10-13. (canceled)
28-47. (canceled)
A pharmaceutical composition comprising:
- a first antagonist for a tyrosine kinase receptor;
- and
- a second antagonist for an integrin receptor.
49-62. (canceled)
Dependencies are inferred from the claim text.