Antibody vaccine conjugates and uses therefor
AssigneeCelldex Therapeutics, Inc.
InventorsTibor Keler, Michael Endres, Lizhen He, Venky Ramakrishna
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Abstract
The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody.
Claims35
A molecular conjugate comprising a monoclonal antibody that binds to human antigen presenting cells (APCs) linked to β human chorionic gonadotropin (βhCG) and to an immunostimulatory agent.
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A composition comprising an immunostimulatory agent and a molecular conjugate of an antibody that binds to APCs linked to βhCG.
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Dependencies are inferred from the claim text.