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US 2016/0355574 A1Published application
Humanized anti-complement factor c1q antibodies and uses thereof
AssigneeAnnexon, Inc.
InventorsArnon Rosenthal, Michael Leviten
Life of this patent
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Abstract
The present disclosure is directed to humanized anti-C1q antibodies and methods of using them.
Claims29
A humanized antibody that specifically binds to a C1q protein, wherein the antibody comprises a heavy chain variable region and a human heavy chain constant region, wherein the heavy chain variable region comprises an Fab region and the heavy chain constant region comprises an Fc region, wherein the Fab region specifically binds to the C1q protein, and wherein the Fc region is incapable of:
- (1) binding the C1q protein, (2) inducing complement activity, (3) and/or inducing antibody-dependent cellular cytotoxicity (ADCC).
Dependencies are inferred from the claim text.