Gene therapy for alzheimer's and other neurodegenerative diseases and conditions
AssigneeCornell University
InventorsRonald G. Crystal, Steven M. Paul
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Abstract
Gene therapy compositions and methods to inhibit or treat neurodegenerative diseases, e.g., Alzheimer's disease, are provided.
Claims27
An isolated recombinant nucleic acid sequence comprising an open reading frame which encodes an antibody directed against tau, wherein the open reading frame comprises nucleic acid sequences for an Ig heavy chain specific for tau and nucleic acid sequences for an Ig light chain specific for tau.
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An adeno-associated virus or lentivirus comprising nucleic acid sequences encoding an Ig heavy chain of an anti-tau antibody, an Ig light chain of an anti-tau antibody or an Ig heavy chain of an anti-tau antibody linked to an Ig light chain of an anti-tau antibody.
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Dependencies are inferred from the claim text.