Norrin regulation of cellular production of junction proteins and use to treat retinal vasculature edema
AssigneeRetinal Solutions LLC
InventorsMichael T. Trese, Antonio Capone, JR., Kimberly Drenser
Life of this patent
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Abstract
A method of tightening inter-cellular junctions in retinal or choroidal vessel cells includes exposing the retinal or choroidal vessel cells to norrin. Upon sufficient contact time, for norrin to selectively up-regulate gene expression of VE-cadherin or claudin-5 in the retinal or choroidal vessel cells, the inter-cellular junctions are tightened. The method is also suitable for treating retinal pigment epithelial cells in wet macular degeneration.
Claims15
A method of tightening inter-cellular junctions in a retinal vessel cells or a choroidal vessel cells defining a tissue comprising:
- administering an effective amount of norrin to the retinal vessel cells or the choroidal vessel cells;
- and
- allowing sufficient time for said norrin to selectively up-regulate gene expression of VE-cadherin and claudin-5 in the retinal vessel cells or the choroidal vessel cells to tighten the inter-cellular junctions of the tissue for prevention of vascular leakage or repair of the vascular leakage.
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Dependencies are inferred from the claim text.