Methods for Treatment of Nephrotic Syndrome and Related Conditions
AssigneeThe UAB Research Foundation
InventorSumant S CHUGH
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Abstract
The present disclosure provides a polypeptide and method for treating and/or preventing nephrotic syndrome, such as but not limited to those associated with minimal change disease and membranous nephropathy, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.
Claims24
A mutant Angptl4 polypeptide having decreased LPL inhibitory activity and increased resistance to cleavage comprising the following structure:
- V-W-X-Y-Z
- wherein
- V is a sequence having at least 95% identity with SEQ ID NO:
- 23, wherein positions 39-55 are not DEMNVLAHGLLQLGQGL, and wherein position 40 is K, A, or E;
- W is an oligopeptide of 0-5 residues;
- X is a sequence having at least 95% identity with SEQ ID NO:
- 24, wherein positions 63-66 are not RRKR;
- Y is an oligopeptide of 0-38 residues;
- and
- Z is a sequence having at least 95% identity with SEQ ID NO:
- 25.
Dependencies are inferred from the claim text.