Mimotopes for use in immunotherapy for shellfish and/or arthropod allergy
AssigneesThe Regents of the University of California, The Chinese University of Hong Kong
InventorsPATRICK LEUNG, KA HOU CHU, YEE YAN WAI, YAT HIN NICKI LEUNG
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Abstract
The present invention provides isolated peptides and nucleic acids encoding the isolated peptides that can modify a subject's immune response to tropomyosin. The isolated peptides correspond to peptide epitope mimics that are based on an invertebrate tropomyosin allergen, e.g., the shrimp tropomyosin Met e 1. Also provided are compositions and methods of use thereof to reduce, minimize or eliminate an allergic response to arthropods and/or shellfish.
Claims36
An isolated peptide having at least about 80% sequence identity to any one of SEQ ID NOS:1-25.
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