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US 2016/0355531 A1Published application
Pharmaceutical Process and Intermediates
AssigneeRigel Pharmaceuticals, Inc.
InventorsBenedict McKeever, Louis Joseph Diorazio, Martin Francis Jones, Leigh Ferris, Sophie Laure Marie Janbon, Pawel Stanislaw Siedlecki, Gwydion Huw Churchill, Peter Alan Crafts
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Abstract
The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof.
Claims20
A compound which is a triethylammonium salt of the compound of formula (II)
The compound according to claim 10, wherein the stoichiometric ratio of triethylamine to the compound of formula (II) is between 0.5:1 and 2.5:1.
A method forming an amine salt of the compound of formula (II)
- comprising,
- (i) combining a solution of the amine in a polar solvent and water with an amide solvate of the compound of formula (II);
- and
- (ii) filtering the reaction mixture.
1 more element
Dependencies are inferred from the claim text.