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US 2016/0355505 A1Published application
Novel compounds
AssigneeGlaxo Group Limited
InventorsFrancis Louis ATKINSON, Michael David BARKER, John LIDDLE, David Matthew WILSON
Life of this patent
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Abstract
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
Claims1
A compound of formula (I):
- wherein:
- X is CR1 or N;
- Y is CH, C or N;
- R1 is hydrogen, C1-6alkoxy or C1-6alkyl;
- R2 is hydrogen, C1-6alkoxy, halo, —C(O)C1-6alkyl, CN, Halo-C1-6alkyl or C(O)NR4R5;
- R3 is hydrogen or C1-6alkoxy;
- R4 is hydrogen or C1-6alkyl;
- R5 is hydrogen or C1-6alkyl;
- and
- m and n are integers each independently selected from 1 and 2;
- or
- a salt thereof.
9 more elements
Dependencies are inferred from the claim text.