Thiopyranose compound and method for producing same
AssigneeFUJIFILM Corporation
InventorsAkira TAKEDA, Toru WATANABE, Taiji KATSUMATA, Takayuki ITO, Toshihiko SAWADA
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Abstract
There is provided a production method of a thiopyranose compound represented by the following Formula (2) by reacting a compound represented by the following Formula (1) with a sulfur compound. X represents a leaving group. A represents an oxygen atom or a sulfur atom. Further, each of R1A to R4B, R1B to R4B, and R5 represents a hydrogen atom or a specific substituent.
Claims23
A production method of a thiopyranose compound represented by the following Formula (2) by reacting a compound represented by the following Formula (1) with a sulfur compound,
- wherein X represents a leaving group,
- A represents an oxygen atom or a sulfur atom,
- R1A and R1B are the same as or different from each other, and each of R1A and R1B represents a hydrogen atom, a hydroxyl group, a carboxyl group, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C6-20 aryl group, or a C2-20 heterocyclic group,
- R5 represents a hydrogen atom,
- R2A to R4A and R2B to R4B are the same as or different from each other, and each of R2A to R4A and R2B to R4B represents a hydrogen atom, a hydroxyl group, a halogen atom, a cyano group, an azido group, an amino group, a carboxyl group, —OROH, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkoxy group, a C2-6 alkenyloxy group, a C1-6 alkylthio group, a C6-20 aryl group, a C6-20 aryloxy group, a C6-20 arylthio group, a C1-20 acyloxy group, a C1-20 acylimino group, a C3-20 silyloxy group, a C2-20 heterocyclic group, a C2-20 heterocyclic oxy group, or a C2-20 heterocyclic thio group,
- each pair of R2A and R2B, R3A and R3B, and R4A and R4B may be bonded to form a C1-6 alkylidene group,
- two of R1A to R4A and R1B to R4B may be bonded to each other to form a group represented by —O—Y1—O—,
- each of R1A to R4A and R1B to R4B may have a substituent or a protecting group,
- ROH represents a hydroxyl protecting group, and
- Y1 represents a C1-6 alkylene group or a C2-20 silylene group.
A compound represented by the following Formula (2),
- wherein A represents an oxygen atom or a sulfur atom,
- R1A, R1B, and R5 are the same as or different from each other, and each of R1A, R1B, and R5 represents a hydrogen atom, a hydroxyl group, a carboxyl group, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C6-20 aryl group, or a C2-20 heterocyclic group,
- R2B to R4B are the same as or different from each other, and each of R2B to R4B represents a hydrogen atom, a hydroxyl group, a halogen atom, a cyano group, an azido group, an amino group, a carboxyl group, —OROH, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkoxy group, a C2-6 alkenyloxy group, a C1-6 alkylthio group, a C6-20 aryl group, a C6-20 aryloxy group, a C6-20 arylthio group, a C1-20 acyloxy group, a C1-20 acylimino group, a C3-20 silyloxy group, a C2-20 heterocyclic group, a C2-20 heterocyclic oxy group, or a C2-20 heterocyclic thio group,
- R2A to R4B each represent —OROHA, and ROHA represents a C6-20 aryl group, a C6-20 aryloxy C1-6 alkyl group, a C7-20 aroyl group, a C6-20 arylsulfonyl group, or a C6-20 aryl C1-20 silyl group,
- each of R1A to R4A, R1B to R4B, and R5 may have a substituent or a protecting group,
- ROH represents a hydroxyl protecting group.
Dependencies are inferred from the claim text.