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US 2016/0355478 A1Published application
Therapeutic agents
AssigneeCancer Research Technology Limited
InventorsBernard Thomas GOLDING, Christiane RIEDINGER, Roger John GRIFFIN, Ian Robert HARDCASTLE, Eric VALEUR, Anna Frances WATSON, Martin NOBLE
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Abstract
A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
Claims22
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is O;
- R1 is selected from substituted aralkyl and substituted heteroaralkyl;
- R2 is substituted or unsubstituted alkylamine;
- R3 is 4-chlorophenyl;
- and
- R4-R7 represents groups R4, R5, R6 and R7 which are independently selected from hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaralkyl, substituted or unsubstituted alkylamine, substituted or unsubstituted alkoxy, trifluoromethyl, amino, nitro, carboxyl, carbonylmethylsulfone, trifluoromethylsulfone, cyano and substituted or unsubstituted sulfonamide.
4 more elements
6-11. (canceled)
(canceled)
Dependencies are inferred from the claim text.