3,3'-disubstituted indolines as inhibitors of cholesterol ester transfer protein

A compound of Formula I, or a pharmaceutically acceptable salt thereof:

• Wherein 1-2 carbon atoms in the phenyl ring of Formula I are optionally replaced with 1-2 heteroatoms selected from NH, S, and O to create a 5-6 membered heteroaromatic ring, wherein:
• Each R1 is independently —C1-C5 alkyl, —OC1-C5 alkyl, —C2-C5 alkenyl, —OC2-C5 alkenyl, —C2-C5 alkynyl, —OC2-C5 alkynyl, —OH, halogen, —CN, —NR9R10, —CO2R8, —C(O)NR9R10, —SO2NR9R10, HET(1), phenyl, or C3-6 cycloalkyl optionally having 1-2 double bonds, wherein —C1-C5 alkyl, —OC1-C5 alkyl, —C2-C5 alkenyl, —OC2-C5 alkenyl, —C2-C5 alkynyl, and —OC2-C5 alkynyl are each optionally substituted with 1-9 halogens, and wherein HET(1), phenyl, and C3-6 cycloalkyl optionally having 1-2 double bonds are optionally substituted with 1-3 substituent groups which are each independently halogen, —C1-C3 alkyl, —OC1-C3 alkyl, —C2-C3 alkenyl, —OC2-C3 alkenyl, —C2-C3 alkynyl, or —OC2-C3 alkynyl, wherein —C1-C3 alkyl, —OC1-C3 alkyl, —C2-C3 alkenyl, —OC2-C3 alkenyl, —C2-C3alkynyl, and —OC2-C3 alkynyl are each optionally substituted with 1-7 halogens;
• R2, R3, R4, R5, R6, and R7 are each independently H, —C1-C5 alkyl, —OC1-C5 alkyl, —C2-C5 alkenyl, —OC2-C5 alkenyl, —C2-C5 alkynyl, —OC2-C5 alkynyl, —OH, halogen, —CN, —NR9R10, —CO2R8, —C(O)NR9R10, —SO2NR9R10, HET(1), phenyl, or C3-6 cycloalkyl optionally having 1-2 double bonds, wherein —C1-C5 alkyl, —OC1-C5 alkyl, —C2-C5 alkenyl, —OC2-C5 alkenyl, —C2-C5 alkynyl, and —OC2-C5 alkynyl are each optionally substituted with 1-9 halogens, and wherein HET(1), phenyl, and C3-6 cycloalkyl optionally having 1-2 double bonds, are optionally substituted with 1-3 substituent groups which are each independently halogen, —C1-C3 alkyl, —OC1-C3 alkyl, —C2-C3 alkenyl, —OC2-C3 alkenyl, —C2-C3 alkynyl, or —OC2-C3 alkynyl, wherein —C1-C3 alkyl, —OC1-C3 alkyl, —C2-C3 alkenyl, —OC2-C3 alkenyl, —C2-C3 alkynyl, and —OC2-C3 alkynyl are each optionally substituted with 1-7 halogens;
• R8 is H or —C1-5alkyl optionally substituted with 1-9 halogens;
• R9 and R10 are each independently H, —C1-C5 alkyl, —C2-C5 alkenyl, —C2-C5 alkynyl, phenyl, C3-6 cycloalkyl optionally having 1-2 double bonds, or HET(1), wherein phenyl, C3-6 cycloalkyl optionally having 1-2 double bonds, and HET(1) are optionally substituted with 1-3 substituent groups which are each independently halogen, —C1-C3 alkyl, —OC1-C3 alkyl, —C2-C3 alkenyl, —OC2-C3 alkenyl, —C2-C3 alkynyl, or —OC2-C3 alkynyl, wherein —C1-C3 alkyl, —OC1-C3 alkyl, —C2-C3 alkenyl, —OC2-C3 alkenyl, —C2-C3alkynyl, and —OC2-C3 alkynyl are each optionally substituted with 1-7 halogens;
• HET(1) is a 3-7 membered heterocyclic or heteroaromatic ring having 1-4 heteroatoms or heteroatom groups which are each independently N, NH, O, S, S(O), or S(O)2 and optionally having 1-3 double bonds;
• Ar1 and Ar2 are each independently phenyl, naphthyl, C3-6 cycloalkyl optionally having 1-2 double bonds, or HET(1), wherein Ar1 and Ar2 are each optionally substituted with 1-5 substituents which are independently —C1-C5 alkyl, —OC1-C5 alkyl, —C2-C5 alkenyl, —OC2-C5 alkenyl, —C2-C5 alkynyl, —OC2-C5 alkynyl, —OH, halogen, —CN, —NR9R10, —CO2R8, —SO2C1-C5alkyl, —C(O)C1-C5 alkyl, —C(O)NR9R10, —SO2NR9R10, or —NR9C(O)NR9R10, and optionally 1-2 substituents which are phenyl, C3-6 cycloalkyl optionally having 1-2 double bonds, HET(1), or HET(2), wherein —C1-C5 alkyl, —OC1-C5 alkyl, —C2-C5 alkenyl, —OC2-C5 alkenyl, —C2-C5 alkynyl, —OC2-C5 alkynyl, —SO2C1-C5alkyl, and —C(O)C1-C5 alkyl are optionally substituted with 1-9 halogens, and wherein when phenyl, C3-6 cycloalkyl optionally having 1-2 double bonds, HET(1), and HET(2) are substituents on Ar1 and Ar2, then phenyl, C3-6 cycloalkyl optionally having 1-2 double bonds, HET(1), and HET(2) are optionally substituted with 1-3 substituent groups which are each independently halogen, —OH, —CN, —NR9R10, —CO2R8, —C1-C3 alkyl, or —OC1-C3 alkyl, wherein —C1-C3 alkyl and —OC1-C3 alkyl are optionally substituted with 1-7 halogens and optionally with 1-2 groups which are —OH, halogen, —CN, —NR9R10, and —CO2R8;
• HET(2) is a bicyclic or spirocyclic heterocycle having two 3-6 membered heterocyclic rings which are fused or are connected through a single carbon atom to make a spirocyclic connection, wherein HET(2) has 2-4 heteroatoms or heteroatom groups which are O, S, S(O)2, N, or NH, and optionally comprises 1-2 double bonds;
• and
• n is 0 or an integer from 1-4.