Process for preparing mesotrione
AssigneeRotam Agrochem International Company Limited
InventorJames Timothy Bristow
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Abstract
A process for the preparation of mesotrione enolate is provided. The process comprises providing a solution of mesotrione in an organic solvent and contacting the solution with a moderate base in the presence of water at a pH of from 6 to 8, to form an aqueous mesotrione enolate solution. A process for preparing mesotrione from the products of an enol ester rearrangement of 3-oxocyclohex-1-enyl-4-(methylsulfonyl)-2-nitrobenzoate is also provided. The process comprises contacting the products of the rearrangement reaction with an organic solvent to dissolve mesotrione; and contacting the resulting solution with an aqueous solution of an acid.
Claims61
A process for the preparation of mesotrione enolate, the process comprising providing a solution of mesotrione in an organic solvent and contacting the solution with a moderate base in the presence of water at a pH of from 6 to 8, to form an aqueous mesotrione enolate solution.
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A process for preparing mesotrione from the products of an enol ester rearrangement of 3-oxocyclohex-1-enyl-4-(methylsulfonyl)-2-nitrobenzoate, the process comprising:
- contacting the products of the said rearrangement reaction with an organic solvent to dissolve mesotrione;
- and
- contacting the resulting solution with an aqueous solution of an acid.
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A process for the preparation of mesotrione, the process comprising:
- conducting an enol ester rearrangement of 3-oxocyclohex-1-enyl-4-(methylsulfonyl)-2-nitrobenzoate by forming a reaction mixture comprising 3-oxocyclohex-1-enyl-4-(methylsulfonyl)-2-nitrobenzoate, an organic solvent, a moderate base sufficient to obtain mesotrione, and a cyanide ion source;
- wherein the enol ester rearrangement is carried out in the absence of a phase transfer catalyst, a transition metal salt and an azole.
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A process for preparing mesotrione, the process comprising:
- providing a solution of mesotrione in an organic solvent;
- and
- crystallizing mesotrione from the organic solvent batch-wise.
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Dependencies are inferred from the claim text.