Preparation of 18F-FLUCICLOVINE

1) A system for carrying out a method to prepare 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) comprising:

• (a) a solid phase having compound of Formula II adsorbed on its surface
• wherein:
• PG1 is a carboxy protecting group;
• and,
• PG2 is an amine protecting group;
• (b) a source of PG1 deprotecting agent to be reacted with said compound of Formula II;
• (c) a source of elution solution to be passed through said solid phase to obtain an eluted compound of Formula III:
• (d) a source of PG2 deprotecting agent to be reacted with said compound of Formula III to obtain a reaction mixture comprising [18F]-FACBC;
• (e) a reaction container;
• and,
• (f) a waste means;
• wherein said system further comprises means permitting sequential flow from:
• (i) (e) to (a);
• (ii) (b) to (a);
• (iii) (a) to (f);
• (iv) (c) to (e) via (a);
• and,
• (v) (d) to (e).