Back to results
US 2016/0355452 A1Published application
Method for producing (bromomethyl)cyclopropane and (bromomethyl)cyclobutane
AssigneeMelchior Material and Life Science France
InventorOlivier GUERRET
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for obtaining high purity (bromomethyl)cyclopropane and (bromomethyl)cyclobutane, starting respectively with cyclopropylmethanol and cyclobutylmethanol, under synthesis conditions that enable high productivity and high yield.
Claims13
Method for preparing a compound (A) of the following formula:
- in which R is a cyclobutane or cyclopropane group, comprising the following steps:
- a) solubilizing a triarylphosphite in a polar aprotic solvent,
- b) adding a bromine compound at a temperature of less than 15° C.,
- c) lowering the temperature to less than 0° C. after completion of the reaction of the bromine with the triarylphosphite,
- d) adding cyclobutylmethanol or cyclopropylmethanol at a temperature of less than 0° C.,
- e) recovering the compound (A).
3 more elements
Dependencies are inferred from the claim text.