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US 2016/0354596 A1Published application
Active-agent inserts for connectors and related methods
AssigneeAttwill Medical Solutions Steriflow L.P.
InventorAttilio DiFiore
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AssigneeAttwill Medical Solutions Steriflow L.P.
InventorAttilio DiFiore
Estimating the term…
A method of tuning the release of an active agent from a cartridge disposed in a catheter and related cartridges are disclosed herein. In one embodiment, a method of tuning the release of an active agent from a cartridge disposed in a catheter convector is provided. The method can include establishing a desired release profile for an active agent to be delivered into a catheter, and disposing a cartridge having the active agent associated therewith into a fluid pathway of a catheter connector of the catheter. Thus, when an aqueous solution contacts and passes by the cartridge, the active agent is released from the cartridge at the desired release profile.
A method of tuning the release of an active agent from a cartridge adapted for insertion into a catheter connector, comprising:
An insert for a luer-type catheter connection, comprising a cartridge adapted for insertion into a fluid pathway of a catheter connector, the cartridge having a lyophilized active agent associated therewith, wherein the cartridge is configured to release the lyophilized active agent into the catheter when fluid is passed along or through the cartridge.
An insert for a luer-type catheter connection, comprising a cartridge adapted for insertion into a fluid pathway of a catheter connector, the cartridge having a chemically modified active agent associated therewith, wherein the chemically modified active agent is modified to alter a release profile compared to an unmodified active agent, and wherein the cartridge is configured to release the chemically modified active agent into the catheter when fluid is passed along or through the cartridge.
An insert for a luer-type catheter connection, comprising a cartridge adapted for insertion into a fluid pathway of a catheter connector, the cartridge having an active agent associated therewith and a coating layer applied to one or both of the cartridge or the active agent, wherein the coating layer is adapted or formulated to control release of the active agent into the catheter when fluid is passed along or through the cartridge.
An insert for a luer-type catheter connection, comprising a cartridge adapted for insertion into a fluid pathway of a catheter connector, the cartridge having an active agent associated therewith, wherein the cartridge has a porosity configured to control release of the active agent into the catheter when fluid is passed along or through the cartridge.
An insert for a luer-type connection, comprising a cartridge adapted for insertion into a fluid pathway of a catheter or fluid directing device, the cartridge having a pharmaceutical agent associated therewith, wherein the cartridge is adapted to release pharmaceutical agent into the catheter or fluid directing device when fluid is passed along or through the cartridge.
A method of tuning the release of an active agent from a cartridge adapted for insertion into a catheter connector, comprising:
The method of claim 0, wherein the lyophilization process is carried out by freezing the active agent in the presence of the cartridge at a temperature ranging from −30 C to −80 C, and vacuuming the cartridge 10 to 50 millitorr.
Dependencies are inferred from the claim text.