Bone pastes comprising biofunctionalized calcium phosphate cements with enhanced cell functions for bone repair
AssigneeUniversity of Maryland, Baltimore
InventorHuakun XU
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Abstract
The invention provides injectable, biofunctional agent-containing calcium phosphate cement bone pastes for bone tissue engineering, and methods of making and using the same.
Claims67
A bone paste comprising calcium phosphate cement and one or more biofunctional agents, wherein the biofunctional agents are selected from the group consisting of RGD-containing peptides, fibronectin, fibronectin-like engineered polymer protein (FEPP), derived extracellular matrix (dECM), and platelet concentrate.
A bone paste comprising calcium phosphate cement, one or more biofunctional agents and cell-encapsulating microbeads, wherein the biofunctional agents are selected from the group consisting of RGD peptide, fibronectin, fibronectin-like engineered polymer protein (FEPP), derived extracellular matrix (dECM), and platelet concentrate.
A method for preparing a bone paste, comprising covalently linking an RGD-containing peptide to chitosan to form RGD-grafted chitosan, dissolving the RGD-grafted chitosan in water to form a chitosan liquid, and mixing calcium phosphate cement into the chitosan liquid, thereby preparing a bone paste.
Dependencies are inferred from the claim text.