Cage amine ligands for metallo-radiopharmaceuticals
AssigneeThe University of Melbourne
InventorsPaul Donnelly, Brett Paterson
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Abstract
The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to a biological entity are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
Claims20
A compound of the formula (III):
- wherein Lig is a nitrogen containing macrocyclic metal ligand;
- L is a bond or a linking moiety;
- L1 is a spacer group;
- R is a moiety capable of binding to a biological entity or a protected form thereof or a synthon thereof.
A compound according to claim 1 wherein Lig is selected from the group consisting of:
- wherein R1 is as defined in claim 24.
Dependencies are inferred from the claim text.