Activated neurotensin molecules and the uses thereof
AssigneesVect-Horus, Centre National De La Recherche Scientifique
InventorsGUILLAUME JACQUOT, PASCALINE LECORCHE, MICHEL KHRESTCHATISKY
Life of this patent
Estimating the term…
Abstract
The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions of the invention may be used e.g., to reduce body temperature, attenuate or halt seizures, reduce excitotoxicity, promote neuroprotection, reduce neuroinflammation and aberrant axonal sprouting or reduce pain.
Claims26
1-19. (canceled)
A compound comprising a neurotensin polypeptide covalently coupled to an activator group, the activator group comprising the amino acid sequence M-aa1-R-L-R wherein aa1 is Proline or an analog thereof.
The compound of claim 22, wherein the neurotensin polypeptide comprises SEQ ID NO:
- 2 or an analog thereof having a biological activity of neurotensin.
A compound selected from compounds I to XX as listed in Table A.
Dependencies are inferred from the claim text.