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US 2016/0354475 A1Published application
Acid-Labile Lipophilic Prodrugs of Cancer Chemotherapeutic Agents
AssigneeArbor Therapeutics, LLC
InventorsJames D. McChesney, John T. Henri, Sylesh Kumar Venkataraman, Mahesh Kumar Gundluru
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Abstract
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of chemotherapy associated with the administration of a cancer chemotherapeutic agent to a patient in need thereof.
Claims16
-17. (canceled)
An acid labile lipophilic molecular conjugate (ALLMC) of the formula 1:
- wherein:
- R is a 2′ hydroxyl residue of a paclitaxel, a docetaxel or an abeo-taxane compound;
- R1 is hydrogen;
- R2 is a C5-C22 alkyl;
- Y is selected from O, NR′ or S wherein R′ is hydrogen or C1-C6 alkyl;
- Z is O or S;
- Q is O;
- and T is O;
- or an enantiomer, diastereoisomer or mixtures thereof;
- and
- a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.