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AssigneeB.G. Negev Technologies and Applications Ltd.
InventorsSmadar Cohen, Olga Kryukov, Emil Ruvinov, Efrat Forti, Stav Shamir
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The present invention provides an anionic polyplex formed from a nucleic acid and an anionic polymer and further comprising a cation, which can be in the form of a nanoparticle or a microparticle and compositions comprising the anionic polyplex. The present invention further provides uses of the anionic polyplex such as delivery of the nucleic acid into cells and methods of treating a disease, disorder or condition selected from the group consisting of cancer, a metabolic, a neurodegenerative, a cardiovascular, and an infectious or inflammatory disease or disorder. The present invention also provides an anionic complex comprising a divalent cation and a nucleic acid but lacking an anionic polymer, in the form of a nanoparticle that is capable of forming a colloidal suspension.
An anionic polyplex in the form of a nanoparticle or a microparticle formed from a nucleic acid and an anionic polymer and further comprising a cation, wherein said anionic polyplex has a diameter of 50-200 nm.
A method of treating a disease, disorder or condition selected from the group consisting of cancer or metabolic, neurodegenerative, cardiovascular, infectious or inflammatory diseases or disorders, comprising:
A stable anionic complex comprising a calcium cation and a nucleic acid but lacking an anionic polymer, wherein said stable anionic complex is in the form of a nanoparticle and capable of forming a colloidal suspension.
Dependencies are inferred from the claim text.