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US 2016/0354470 A1Published application
Sustained-release drug carrier composition
AssigneePolypid Ltd.
InventorNoam EMANUEL
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Abstract
The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
Claims74
A matrix composition comprising:
- a. a biodegradable polymer in association with a first lipid having a polar group;
- b. a second lipid comprising at least one phospholipid having hydrocarbon chains of at least 14 carbons;
- c. a pharmaceutical active agent;
- where the matrix composition is adapted for providing sustained release of the pharmaceutical active agent.
1 more element
A method of producing a matrix composition, said method comprising the steps of:
- a. mixing into a first volatile organic solvent:
- (i) a biodegradable polymer and (ii) a first lipid having a polar group;
- b. mixing into a second volatile organic solvent:
- (i) at least one pharmaceutical active agent;
- (ii) a second lipid selected from phospholipids having hydrocarbon chains of at least 14 carbons;
- and
- c. mixing the products resulting from steps (a) and (b), to produce a homogeneous mixture;
- and
- d. evaporating the volatile organic solvents;
- thereby producing a homogeneous matrix composition.
7 more elements
A matrix composition comprising:
- a. a biodegradable polymer in association with a first lipid having a polar group;
- b. a second lipid comprising at least one phospholipid having hydrocarbon chains of at least 14 carbons;
- c. at least one pharmaceutical active agent;
- wherein the matrix composition is essentially devoid of water and is adapted for providing sustained release of the pharmaceutical active agent.
1 more element
A method of producing a matrix composition, said method comprising the steps of:
- a. mixing into a first volatile organic solvent:
- (i) a biodegradable polymer and (ii) a first lipid having a polar group;
- b. mixing into a second volatile organic solvent:
- (i) at least one pharmaceutical active agent;
- (ii) a second lipid selected from phospholipids having hydrocarbon chains of at least 14 carbons;
- and c. mixing the products resulting from steps (a) and (b), to produce a homogeneous mixture;
- and d. evaporating the volatile organic solvents;
- wherein each step of said method is substantially free of an aqueous solution, thereby producing a homogeneous matrix composition.
5 more elements
Dependencies are inferred from the claim text.