Compositions and methods for modulating an immune response
AssigneeThe Johns Hopkins University
InventorsCharles G. Drake, Drew M. Pardoll, Jonathan D. Powell, Derese Getnet, Edward L. Hipkiss, Joseph F. Grosso
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Abstract
The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.
Claims27
-2. (canceled)
A method for increasing an effector T cell-mediated immune response, the method comprising contacting the cell with an agent that reduces Helios expression or biological activity, thereby increasing the immune response.
(canceled)
A method for increasing an effector T cell-mediated immune response in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent that reduces Helios expression or biological activity, thereby increasing the immune response.
-16. (canceled)
A method for increasing the efficacy of an anti-neoplasia vaccine in a subject, the method comprising administering to the subject a vaccine comprising a tumor antigen and an agent that reduces the level or activity of a Helios polypeptide in a cell of the subject.
-62. (canceled)
Dependencies are inferred from the claim text.