Compositions and methods for modulation of immune response
AssigneeNorthwestern University
InventorChristian Stehlik
Life of this patent
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Abstract
Provided herein are compositions and methods for modulation of immune response via PYRIN domain-only proteins POP1 and/or POP3. In particular, POP1 and/or POP3 are inhibited to enhance an immune response (e.g., to treat or prevent infection), or POP1 and/or POP3 are administered or activated to reduce an immune response (e.g., to treat or prevent autoimmune or inflammatory disease).
Claims21
A method of treating or preventing a disease or condition associated with inflammation comprising administering a composition that increases the activity of POP1, POP2, and/or POP3.
A method of treating or preventing infection comprising administering a composition that inhibits the activity of POP1, POP2, and/or POP3.
The POP1, POP2, or POP3 protein, polypeptide, or peptide that comprises less than 100% sequence identity, but greater than 70% sequence identity with all or a portion of POP1, POP2, or POP3.
A POP1, POP2, or POP3 protein, polypeptide, or peptide for use as a medicament.
A POP1, POP2, or POP3 protein, polypeptide, or peptide for use as a medicament.
A POP1, POP2, or POP3 protein, polypeptide, or peptide for use in the treatment or prevention of an autoimmune or inflammatory disease or condition.
A POP1, POP2, or POP3 protein, polypeptide, or peptide for use in the treatment or prevention of an autoimmune or inflammatory disease or condition.
A POP1, POP2, or POP3 inhibitor.
Dependencies are inferred from the claim text.