Compositions and Formulations for Increasing Renal Function and Treatment and Prevention of Renal Diseases, and Methods of Production and Use Thereof

A nutritive formulation for the treatment or prevention of a muscle wasting disease, disorder or condition in a human subject suffering from a renal disease, comprising an isolated nutritive polypeptide comprising an amino acid sequence at least about 90% identical over at least about 50 amino acids to a polypeptide sequence selected from the group consisting of SEQID 00001-03909;

• wherein the nutritive polypeptide is present in an amount sufficient to provide a nutritional benefit to a human subject having or at risk of having reduced protein absorption capacity;
• wherein the isolated nutritive polypeptide has an aqueous solubility at pH 7 of at least 12.5 g/L and wherein the isolated nutritive polypeptide has a simulated gastric digestion half-life of less than 30 minutes.

-64. (canceled)

A method of treating or reducing the severity of a renal disease in a human subject, comprising administering to the human subject a nutritional formulation in an amount sufficient to treat or prevent the renal disease, wherein the nutritional formulation comprises an isolated nutritive polypeptide comprising an amino acid sequence at least about 90% identical over at least about 50 amino acids to a polypeptide sequence selected from the group consisting of SEQID 00001-03909.