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US 2016/0354435 A1Published application
Norrin regulation of junction proteins and the use thereof to treat epithelial or endothelial membrane leakage induced edema
AssigneeRetinal Solutions LLC
InventorsMichael T. Trese, Antonio Capone, JR., Kimberly Drenser
Life of this patent
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Abstract
A method of tightening inter-cellular junctions in endothelial or epithelial cells includes exposing the endothelial or epithelial cells cells to norrin. Upon sufficient contact time, for norrin to selectively up- regulate gene expression of Cadherin or claudin-5 in the endothelial or epithelial cells, the inter-cellular junctions are tightened.
Claims16
A method of tightening inter-cellular junctions in endothelial or epithelial cells defining a tissue comprising:
- administering an effective amount of norrin to the endothelial or epithelial cells;
- and
- allowing sufficient time for said norrin to selectively up-regulate gene expression of Cadherin and claudin-5 in the endothelial or epithelial cells to tighten the inter-cellular junctions of the tissue for prevention of vascular leakage or repair of the vascular leakage.
Dependencies are inferred from the claim text.