Treatment of cancer by manipulation of commensal microflora
AssigneeThe University of Chicago
InventorsThomas F. Gajewski, Ayelet Sivan, Leticia Corrales
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Abstract
Provided herein are methods of treatment and/or prevention of cancer by manipulation of commensal microflora. In particular, the amount, identity, presence, and/or ratio of microflora (e.g., gut microflora) in a subject is manipulated to facilitate one or more co-treatments.
Claims30
A method of treating cancer in a human subject comprising administering to the subject an immune checkpoint inhibitor and a bacterial formulation comprising bacteria of the genera Bifidobacterium.
The method of claim 9, wherein the administration of the two or more doses are separated by at least 1 week.
A method of treating cancer in a human subject comprising administering to the subject a bacterial formulation comprising at least 5×106 CFU of bacteria of the genera Bifidobacterium, wherein at least 50% of the bacteria in the bacterial formulation are of the genera Bifidobacterium.
Dependencies are inferred from the claim text.