Back to results
US 2016/0354404 A1Published application
Compositions and Methods for Inhibition of PCSK9 Genes
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsGregory Hinkle, Maria Frank-Kamenetsky, Kevin Fitzgerald
Life of this patent
Estimating the term…
Abstract
The invention relates to sirens targeting a PCs gene, and methods of using sirens to inhibit expression of PCs and to treat PCs related disorders, e.g., hyperlipidemia.
Claims18
-38. (canceled)
A method for treating hypercholesterolemia in a subject heterozygous for an LDLR gene comprising administering to the subject an effective amount of a dsRNA for inhibiting expression of PCSK9, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a PCSK9 RNA transcript and the dsRNA is 30 base pairs or less in length.
Dependencies are inferred from the claim text.