Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorByeong-Chel Lee
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Abstract
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobilizing compound (for example, but not limited to G-CSF), to mobilize hematopoietic progenitor cells for transplant or other purposes. The methods of the invention may be particularly advantageous as applied to improve the stem cell yield in so-called “poor mobilizing” patients.
Claims13
1-27. (canceled)
A pharmaceutical composition comprising a uridine diphosphate (UDP) compound and a second hematopoietic cell mobilizing compound.
A pharmaceutical composition comprising a uridine diphosphate (UDP) compound and a second hematopoietic cell mobilizing compound, in an amount effective to mobilize hematopoietic stem cells from the bone into peripheral circulation of a subject in need thereof.
Dependencies are inferred from the claim text.