Substituted gemcitabine aryl amide analogs

A composition comprising:

• a compound, or pharmaceutically acceptable salt, solvate, or polymorph thereof, having a structure of formula (I):
• wherein:
• R1a and R1e are independently selected from hydrogen, fluoro, chloro, bromo, iodo, methyl, methoxy, fluoromethyl, fluoromethoxy, difluoromethyl, difluoromethoxy, trifluoromethyl, trifluoromethoxy, ethyl, ethoxy, propyl, propoxy, butyl, butoxy, cyano, hydroxy, thiol, alkylthiol, optionally substituted benzyl, optionally substituted phenoxy, nitro, amino, monoalkylamino, and dialkylamino;
• R1b and R1d are independently selected from hydrogen, fluoro, chloro, bromo, iodo, methyl, methoxy, fluoromethyl, fluoromethoxy, difluoromethyl, difluoromethoxy, trifluoromethyl, trifluoromethoxy, ethyl, ethoxy, propyl, propoxy, butyl, butoxy, cyano, hydroxy, thiol, alkylthiol, optionally substituted phenyl, optionally substituted benzyl, optionally substituted phenoxy, nitro, amino, monoalkylamino, and dialkylamino;
• R1c is selected from hydrogen, fluoro, chloro, bromo, iodo, methyl, methoxy, fluoromethyl, fluoromethoxy, difluoromethyl, difluoromethoxy, trifluoromethyl, trifluoromethoxy, ethyl, ethoxy, propyl, propoxy, butyl, butoxy, cyano, hydroxy, thiol, alkylthiol, optionally substituted phenyl, optionally substituted benzyl, optionally substituted phenoxy, —C(O)R5, —C(O)OR5, —C(O)NHR5, —OC(O)R5, —NHC(O)R5, and —NHC(O)OR5;
• at least one of R1a, R1b, R1c, R1d, and R1e is not hydrogen;
• R5 is hydrogen, methyl, ethyl, propyl, butyl, pentyl, or hexyl;
• R2 is selected from hydrogen, C1-C4 alkyl, and amine protecting group;
• R3 is selected from hydrogen and hydroxyl protecting group;
• R4 is selected from hydrogen, C1-C8 alkyl, and hydroxyl protecting group;
• or R3 and R4 together comprise a divalent moiety having a structure represented by a formula:
• and
• each R6 is independently selected from methyl, ethyl, propyl, and butyl;
• and
• an additional therapeutic compound.