Method to enhance tissue regeneration
AssigneesChildren's Medical Center Corporation, The General Hospital Corporation
InventorsLeonard I. ZON, Trista E. NORTH, Wolfram GOESSLING
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Abstract
The present invention provides for compositions and methods for modulating tissue growth using tissue growth modulators, which are agents that either enhance or inhibit tissue growth as desired by a particular indication by modulating the PG or Wnt signaling pathways, or employing modulators of both PG and Wnt signaling pathways for a synergistic effect or highly selective effect.
Claims22
1-3. (canceled)
A pharmaceutical composition comprising at least one prostaglandin signaling pathway activator and a wnt pathway activator, wherein the at least one prostaglandin signaling pathway activator is a PGE2 receptor agonist.
A pharmaceutical composition comprising at least one prostaglandin signaling pathway activator or a downstream mediator of the prostaglandin signaling pathway, and a wnt pathway activator;
- wherein the at least one prostaglandin signaling pathway activator is a PGE2 receptor agonist;
- wherein the downstream mediator of the prostaglandin signaling pathway is selected from the group consisting of:
- Forskolin, 8-bromo-cAMP, Sp-5,6,-DCI-cBiMPS, Bapta-AM, Fendiline, Nicardipine, Nifedipine, Pimozide, Strophanthidin, and Lanatoside;
- and
- wherein the wnt pathway activator is selected from the group consisting of a GSK-3 inhibitor and a soluble Wnt ligand.
A method for promoting tissue growth or regeneration, comprising:
- contacting a tissue with at least one prostaglandin signaling pathway activator or a downstream mediator of the prostaglandin signaling pathway, and a wnt pathway activator;
- wherein the at least one prostaglandin signaling pathway activator is a PGE2 receptor agonist;
- wherein the downstream mediator of the prostaglandin signaling pathway is selected from the group consisting of:
- Forskolin, 8-bromo-cAMP, Sp-5,6,-DCI-cBiMPS, Bapta-AM, Fendiline, Nicardipine, Nifedipine, Pimozide, Strophanthidin, and Lanatoside;
- and
- wherein the wnt pathway activator is selected from the group consisting of a GSK-3 inhibitor and a soluble Wnt ligand.
A method for promoting tissue growth or regeneration, comprising:
- contacting a tissue the tissue with a prostaglandin signaling pathway activator, and a wnt pathway activator;
- wherein the prostaglandin signaling pathway activator is a PGE2 receptor agonist;
- and
- wherein the wnt pathway activator is selected from the group consisting of a GSK-3 inhibitor and a soluble Wnt ligand.
Dependencies are inferred from the claim text.