Pharmaceutical Compositions
AssigneeAlpharma Pharmaceuticals, LLC
InventorsAlfred Liang, Franklin Johnson, Xiaohong Qi
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Abstract
Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
Claims25
A pharmaceutical composition comprising oxycodone, an antagonist of oxycodone, a seal coat, and at least one sequestering polymer, wherein the seal coat physically separates the oxycodone from the antagonist in the intact form of the composition.
A pharmaceutical composition comprising oxycodone and an antagonist of oxycodone on a sealed sugar sphere, wherein the oxycodone and antagonist are separated by a substantially impermeable barrier comprising a sequestering polymer, charge-neutralizing additive, and a sequestering polymer hydrophobicity-enhancing additive, wherein the agonist is substantially released and the antagonist is substantially sequestered upon administration to a human being.
Dependencies are inferred from the claim text.