Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions

A method for treating a skin disease or condition in a subject in need of such treatment, the method comprising administering to the subject a therapeutically effective amount of a composition comprising a compound of Formula II:

• wherein:
• R1 is H or optionally substituted C1-3 alkyl;
• R2 is H or optionally substituted C1-3 alkyl;
• R3 is H, optionally substituted C1-10 alkyl, optionally substituted heterocycle or optionally substituted aryl;
• and
• R is optionally substituted C1-10 alkyl, optionally substituted heterocycle or optionally substituted aryl;
• or
• a pharmaceutically acceptable salt thereof;
• and
• one or more selected from the group consisting of a pharmaceutically acceptable carrier, preservative, auxiliary agent, stabilizing agent, thickening agent, coloring agent and perfume;
• wherein the skin disease or condition is sunburn, chronic sun damage, a discreet erythema, menopause-associated hot flashes, hot flashes resulting from orchiectomyatopic dermatitis, telangiectasia of the face, or cutaneous hyperactivity with dilation of blood vessels of the skin.