Lipoic acid choline ester compositions and methods of use
AssigneeEncore Vision Inc.
InventorsWilliam H. GARNER, Margaret H. GARNER, William R. BURNS
Life of this patent
Estimating the term…
Abstract
Provided herein are pharmaceutical compositions comprising a therapeutically effective amount of lipoic acid choline ester or derivatives thereof and a non-aqueous excipient mixed in an aqueous solution. Also provided herein are non-aqueous compositions prepared by mixing the therapeutically effective amount of lipoic acid choline ester and the non-aqueous excipient. The non-aqueous compositions can be further mixed with the aqueous solution.
Claims44
A pharmaceutical composition comprising a therapeutically effective amount of lipoic acid choline ester and a non-aqueous excipient, mixed in an aqueous solution having a pH of 4 to 6, wherein at least 95% of the lipoic acid choline ester is present in the pharmaceutical composition, as measured by HPLC, following storage at 25° C. under 40% relative humidity for 3 months.
A non-aqueous composition comprising lipoic acid choline ester or derivatives thereof and a non-aqueous excipient.
A system comprising a first compartment, a second compartment, and a seal separating the first and second compartments, wherein the first compartment comprises a non-aqueous composition of an active ingredient and a non-aqueous excipient, the second compartment comprises an aqueous solution, and wherein the system is activated upon breaking the seal and mixing the non-aqueous solution with the aqueous solution.
A method of storing an active ingredient that is susceptible to hydrolysis in an aqueous solution, the method comprising (a) providing the active ingredient in a first compartment;
- (b) providing the aqueous solution in a second compartment;
- and (c) separating the first and second compartments with a seal, wherein the active ingredient in the first compartment is not in contact with the aqueous solution until just prior to usage by breaking the seal.
Dependencies are inferred from the claim text.