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AssigneeChildren's Medical Center Corporation
InventorsMagdalene M. MORAN, Jayhong A. CHONG, Ian S. RAMSEY, David CLAPHAM
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Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.
A transgenic non-human animal comprising a modification into the non-human animal, the modification comprising an insertion of a nucleic acid encoding a CaSper4 protein, the CatSper4 protein comprising at least 90% similarity to the amino acid sequence of SEQ ID NO:
A transgenic non-human animal comprising a modification into the non-human animal, wherein the modification is replacement of an endogenous CatSper4 protein sequence with a reporter or marker gene, wherein the CatSper4 protein comprises at least 90% similarity to the amino acid sequence of SEQ ID NO:
A transgenic non-human animal comprising a modification into the non-human animal, the modification comprising inactivation of an endogenous CatSper4 protein, wherein the CatSper4 protein comprises at least 90% similarity to the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.