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AssigneeEvonik Degussa GmbH
InventorsJasmin CORTHALS, Katrin GRAMMANN, Thomas HAAS, Maik OLFERT, Nicole POTGRAVE, Liv REINECKE, Steffen SCHAFFER, Jan WOLTER
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The present invention relates to a cell expressing an amino acid-N-acyl-transferase, which is preferably recombinant, and an acyl-CoA synthetase, which is preferably recombinant, wherein the cell has a reduced fatty acid degradation capacity, a method for producing acyl amino acids, comprising the step contacting an amino acid and an acyl CoA in the presence of an amino acid-N-acyl-transferase, which is preferably isolated and/or recombinant, wherein the amino acid-N-acyl-transferase is preferably a human amino acid-N-acyl-transferase, or culturing the cell and a reaction mixture comprising an amino acid-N-acyl-transferase, which is preferably isolated and/or recombinant, an acyl-CoA synthetase, which is preferably isolated and/or recombinant, an amino acid and either a fatty acid-CoA or a fatty acid and an acyl-CoA-synthase.
A cell expressing an amino acid-N-acyl-transferase and an acyl-CoA synthetase, wherein the cell has a reduced fatty acid degradation capacity.
A cell expressing an amino acid-N-acyl-transferase, an acyl-CoA synthetase, and at least one enzyme selected from the group consisting of acetoacetyl-CoA synthase, ketoacyl-CoA synthase, ketoacyl-CoA thiolase, enoyl-CoA reductase, ketoacyl-CoA reductase and 3-hydroxyacyl-CoA dehydratase, wherein the cell optionally exhibits a decrease in the expression of acetoacetyl-CoA thiolase relative to a wild type cell, and wherein the cell has a reduced fatty acid degradation capacity.
A method for producing an acyl amino acid, comprising
A reaction mixture comprising
16-20. (canceled)
Dependencies are inferred from the claim text.