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US 2016/0258967 A1Published application
Methods of diagnosing acute cardiac disorders using bnp-sp
AssigneeOtago Innovation Limited
InventorsChristopher Joseph PEMBERTON, Arthur Mark RICHARDS, Michael Gary NICHOLLS, Timothy Grant YANDLE
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Abstract
The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.
Claims32
An assay method for diagnosing an acute cardiac disorder in a subject, the method comprising:
- a. obtaining a biological sample from the subject;
- b. contacting the sample with a BNP-SP fragment binding agent;
- c. determining the level of a BNP-SP fragment in the biological sample obtained from the subject;
- and
- d. comparing the level of said BNP-SP fragment in the sample with the level of said BNP-SP fragment in a control or reference value,
- wherein a level of BNP-SP fragment in the sample that is higher than the control level is diagnostic of an acute cardiac disorder.
3 more elements
Dependencies are inferred from the claim text.