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AssigneeBerg LLC
InventorsNiven Rajin Narain, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Viatcheslav R. Akmaev
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Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of variety of biomarkers diagnostic of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9. Additionally, age can be used as a predictor variable. The invention also provides methods of treating prostate cancer which rely on diagnostic information obtained based on the detection of biomarkers of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, LY9, and/or age. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
A method for diagnosing the presence of prostate cancer in a subject, comprising:
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A method for diagnosing the presence of prostate cancer in a subject, comprising:
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A method for monitoring prostate cancer in a subject, the method comprising:
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A method of treating prostate cancer in a subject suspected of having prostate cancer, comprising:
A method of treating prostate cancer in a subject, comprising:
A method of treating prostate cancer in a subject suspected of having prostate cancer, comprising:
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A kit for detecting filamin A in a biological sample from a subject having, suspected of having, or at risk for having prostate cancer comprising at least one reagent for measuring the level of filamin A in the biological sample from the subject, and a set of instructions for measuring the level of filamin A in the biological sample from the subject.
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A panel for use in a method of detecting at least two markers for prostate cancer, the panel comprising at least two detection reagents, wherein each detection reagent is specific for the detection of at least one prostate cancer marker of a set of markers, wherein the set of markers comprises filamin A and at least one other prostate cancer related marker selected from the group consisting of filamin B, LY9, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3 and PSA.
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A panel for use in a method of monitoring the treatment of prostate cancer, the panel comprising at least two detection reagents, wherein each detection reagent is specific for the detection of at least one prostate cancer marker of a set of markers, wherein the set of markers comprises filamin A and at least one other prostate cancer related marker selected from the group consisting of filamin B, LY9, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3 and PSA.
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Dependencies are inferred from the claim text.