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AssigneeRamot at Tel-Aviv University Ltd.
InventorsFernando PATOLSKY, Le-Chang HSIUNG, Vadim KRIVITSKY, Vladimir NADDAKA
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Systems and methods for sensing target molecules such as redox reactive agents, comprising a sample compartment and a sensing compartment being in fluid communication, are disclosed. A sensing compartment which comprises nanostructures to which a functional moiety is covalently attached and which is such that upon contacting a redox reactive agent a change in electrical property of the nanostructure occurs, and integration of such a sensing compartment with sensing systems as described herein are also disclosed. Methods of monitoring a metabolic activity of cells, and uses thereof, are also disclosed.
1-44. (canceled)
A method of determining a presence and/or amount of a substance producing a redox reactive agent in at least one fluid sample, the method comprising introducing the at least one sample to a sensing system comprising at least one chamber being in controllable fluid communication with a sensing compartment, said at least one chamber being configured to contain a fluid and said sensing compartment comprising a semiconductor nanostructure and a functional moiety covalently attached to said nanostructure, said functional moiety being a redox reactive moiety and is such that upon contacting a redox reactive agent, said nanostructure exhibits a detectable change in an electrical property, wherein said detectable change in said electrical property is indicative of the presence and/or amount of the substance in each of said at least one sample.
A method of determining a presence and/or amount of a redox reactive agent in at least one fluid sample, the method comprising introducing the at least one sample to a sensing system comprising at least one chamber being in controllable fluid communication with a sensing compartment, said at least one chamber being configured to contain a fluid and said sensing compartment comprising a semiconductor nanostructure and a functional moiety covalently attached to said nanostructure, said functional moiety being a redox reactive moiety and is such that upon contacting a redox reactive agent, said nanostructure exhibits a detectable change in an electrical property, wherein said detectable change in said electrical property is indicative of the presence and/or amount of the redox reactive agent in each of said at least one sample.
A system comprising at least one chamber being in controllable fluid communication with a sensing compartment, said at least one chamber being configured to contain a fluid and said sensing compartment comprising a semiconductor nanostructure and a functional moiety covalently attached to said nanostructure, said functional moiety being a redox reactive moiety and is such that upon contacting a redox reactive agent, said nanostructure exhibits a detectable change in an electrical property.
A sensing system, comprising:
Dependencies are inferred from the claim text.