SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

A method of treating a subject having a hemophilia, comprising administering to the subject a therapeutically effective amount of a double stranded ribonucleic acid (dsRNAi) agent,

• wherein the dsRNAi agent comprises a sense strand and an antisense strand, wherein the antisense strand comprises a region of complementarity which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:5, thereby treating the subject having a hemophilia.

A method of preventing at least one symptom in a subject having a hemophilia, comprising administering to the subject a therapeutically effective amount of a double stranded ribonucleic acid (dsRNAi) agent,

• wherein the dsRNAi agent comprises a sense strand and an antisense strand,
• wherein said sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:1 and said antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:5, thereby preventing at least one symptom in the subject having a hemophilia.

A method of preventing at least one symptom in a subject having a hemophilia, comprising administering to the subject a therapeutically effective amount of a double stranded ribonucleic acid (dsRNAi) agent,

• wherein the dsRNAi agent comprises a sense strand and an antisense strand, wherein the antisense strand comprises a region of complementarity which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:5, thereby preventing at least one symptom in the subject having a hemophilia.