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US 2016/0257953 A1Published application
Costimulatory b7-h1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
AssigneeMayo Foundation for Medical Education and Research
InventorsLieping Chen, Scott E. Strome, Eugene D. Kwon
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Abstract
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
Claims1
A method of inhibiting expression of B7-H1 in a tumor cell or a tumor-infiltrating leukocyte, the method comprising:
- (a) identifying a subject with cancer, the cancer comprising a target cell that expresses B7-H1, the target cell being a tumor cell or a tumor-infiltrating leukocyte;
- and (b) introducing into the target cell:
- (i) an antisense oligonucleotide that hybridizes to a B7-H1 transcript, wherein the antisense oligonucleotide inhibits expression of B7-H1 in the cell;
- or (ii) a B7-H1 interference RNA (RNAi).
1 more element
Dependencies are inferred from the claim text.