Method for producing pluripotent stem cell having improved chimera forming ability from primed pluripotent stem cell, and composition and combination therefor
AssigneeThe University of Tokyo
InventorsHiromitsu Nakauchi, Hideki Masaki, Hideyuki Murayama
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Abstract
The present invention provides a method for putting a primed pluripotent stem cell in a less differentiated state, a method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, and a method for producing a chimeric animal by using the pluripotent stem cell obtained by any of these methods. The present invention also provides a composition containing a Wnt/β catenin signal inhibitor.
Claims12
A method for putting a primed pluripotent stem cell in a less differentiated state, comprising placing a primed pluripotent stem cell in a state where a Wnt/β catenin signal is inhibited and a signal transducer and activator of transcription 3 (STAT3) signal is activated.
A method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, comprising placing a primed pluripotent stem cell in a state where a Wnt/β catenin signal is inhibited and a signal transducer and activator of transcription 3 (STAT3) signal is activated.
A composition for use in improving a chimera forming ability of a primed pluripotent stem cell, comprising a Wnt/β catenin signal inhibitor and a signal transducer and activator of transcription 3 (STAT3) signal activator.
A combination of a signal transducer and activator of transcription 3 (STAT3) signal activator and a Wnt/β catenin signal inhibitor.
A method for improving a chimera forming ability of a primed pluripotent stem cell, comprising introducing E-cadherin into a primed pluripotent stem cell.
A method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, comprising introducing E-cadherin into a primed pluripotent stem cell.
Dependencies are inferred from the claim text.