Tetrahydroquinoline compositions as bet bromodomain inhibitors

A compound of Formula I:

• or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, prodrug, isomer, or tautomer thereof,
• wherein:
• W is O, S, C(O), or CHR3;
• X is N or CR4;
• Y is N or CR6;
• Z is N or CR7;
• R1 is hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;
• R2 is hydrogen or NRaRb;
• R3 is hydrogen, halogen, hydroxyl, C1-C6 alkyl, or C1-C6 haloalkyl;
• R4 is hydrogen, —(CH2)nRd, —O(CH2)nRd, —N(CH2)nRd, —O(CH2)nC(O)Rd, or —O(CH2)nS(O)2Rd;
• R5 and R6 are each independently hydrogen, halogen, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, —(C1-C6)-alkylene-aryl, —(C1-C6)-alkylene-heteroaryl, —(C1-C6)-alkylene-heterocycloalkyl, —(CRaRb)nORc, —(CRaRb)nRc, —O(CRaRb)nNRaRb, —NRaRb, —NRaC(O)Rb, —NRaS(O)2Rb, or Rc, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from Ra, Rb, and Rc;
• R7 is hydrogen or halogen;
• R8 is Ra, —ORa, —NRa, or heterocycloalkyl;
• Ra and Rb are each independently hydrogen, halogen, C1-C6 alkyl, cycloalkyl, or heterocycloalkyl, wherein C1-C6 alkyl, cycloalkyl, or heterocycloalkyl is optionally substituted with one or more Re;
• Rc is —NH2, OH, —NH(C1-C6 alkyl), —O(CH2)nNRaRb, —NH(C1-C6 alkoxy), —(CH2)nRa, —(CH2)nORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —(CH2)nS(O)2CH3, —S(O)2Ra, —S(O)2NRaRb, —NRa—S(O)2Rb, —NHC(O)Ra, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo, cyano, or oxo, wherein C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more Re;
• or two adjacent Rc can combine with the carbons to which they are attached to form a carbocycle or heterocycle;
• Rd is hydrogen, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from Ra, Rb, and Rc;
• Re is hydrogen, halogen, OH, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, oxo, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkoxy, or S(O)2(C1-C6 alkyl);
• and
• n is 0, 1, or 2.