Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition

A compound having the formula (I):

• including hydrates, solvates, enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein:
• A is selected from a group consisting of CR1aR1b, sulfur, oxygen, and NR7;
• X is selected from a group consisting of oxygen, sulfur, and NH;
• Z is
• R1a and R1b are each independently selected from a group consisting of optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl;
• R1a and R1b are taken together with the atoms to which they are bound to form a ring containing 3 to 6 atoms;
• R2 is selected from a group consisting of optionally substituted C3-C7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted biphenyl,
• R3 is selected from a group consisting of hydrogen, C1-C6 alkyl, and C3-C7 cycloalkyl;
• R4 is selected from a group consisting of hydrogen, C1-C6 alkyl, and C3-C7 cycloalkyl;
• R5a nd R5b are at each occurrence independently selected from a group consisting of hydrogen, optionally substituted C1-C6 alkyl, and optionally substituted C3-C7 cycloalkyl;
• R5a and R5b are taken together with the atoms to which they are bound to form a ring containing 3 to 6 atoms;
• R6a nd R6b are at each occurrence independently selected from a group consisting of hydrogen, optionally substituted C1-C6 alkyl, and optionally substituted C3-C7 cycloalkyl;
• R6a and R6b are taken together with the atoms to which they are bound to form a ring containing 3 to 6 atoms;
• R6a and R6b are taken together with the atoms to which they are bound to form a ring containing 3 to 6 atoms;
• R7 is selected from a group consisting of hydrogen, optionally substituted C1-C6 alkyl, and optionally substituted C3-C7 cycloalkyl;
• R8 at each occurrence is independently selected from a group consisting of hydrogen, halogen, cyano, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C8 cycloalkyl, OH, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, NO2, C1-3 haloalkyl, C1-3 haloalkoxy, SH, S (C1-C6 alkyl), and 3-10 membered cycloheteroalkyl containing 1 to 4 heteroatoms selected from N, O and S;
• m=1, 2, 3, or 4;
• n=1, 2, 3, or 4;
• y=0, 1, or 2;
• with the proviso that the compound is not the compound of formula (II):