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US 2016/0257666 A1Published application
Modulators of resistant androgen receptor
AssigneeMemorial Sloan Kettering Cancer Center
InventorsMinna D. Balbas, Michael J. Evans, Charles L. Sawyers, Yang Shen, David Hosfield, Geoffrey L. Greene
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Abstract
The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
Claims12
A compound of formula IV:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is CH or N;
- and
- each Rb is independently a substituted or unsubstituted C1-6 aliphatic;
- and
- n is 0 to 4.
3 more elements
2-6. (canceled)
A method of treating or lessening the severity of a cancer or another proliferative disease, disorder or condition, comprising administering to a patient in need thereof a compound represented by structural formula IV:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is CH or N;
- each Rb is independently substituted or unsubstituted C1-6 aliphatic;
- and
- n is 0 to 4.
2 more elements
Dependencies are inferred from the claim text.