US 2016/0257660 A1 · THIADIAZOLIDINEDIONES AS GSK-3 INHIBITORS

Thiadiazolidinediones as gsk-3 inhibitors

AssigneeAsd Therapeutics Partners, LLC

InventorsMiguel MEDINA PADILLA, Juan Manuel DOMÍNGUEZ CORREA, Javier DE CRISTOBAL BLANCO, Ana FUERTES HUERTA, Jorge SÁNCHEZ-QUESADA, Javier LÓPEZ OGALLA, Susana HERRERO SANTOS, María Ángeles PÉREZ DE LA CRUZ MORENO, Olga MARTÍNEZ MONTERO, Beatriz RODRÍGUEZ SALGUERO, Francisco PALOMO NICOLAU

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Abstract

The present invention relates to new thiadiazolidinediones of formula (I), or any pharmaceutically acceptable salt, solvate or prodrug thereof, and its use in the treatment of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, particularly neurodegenerative diseases, inflammatory and autoimmune diseases and cardiovascular disorders. Additionally, there is provided a process for preparing such compounds, as well as pharmaceutical compositions comprising them.

Claims17

Dependent claims

A compound of Formula (I):

wherein:
Ra is an unsubstituted ethyl, or a methyl group or an ethyl group substituted with hydroxyl or heterocyclyl;
Rb is —(Z)m-aryl;
Z is —C(R2)(R3)—, wherein R2 and R3 are independently selected from hydrogen and alkyl;
m is 1 or 2;
or any pharmaceutically acceptable salt, solvate or prodrug thereof.

3 more elements

Dependencies are inferred from the claim text.