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US 2016/0257651 A1Published application
Novel compound with antibacterial activity
AssigneeJuntendo Educational Foundation
InventorsKeiichi HIRAMATSU, Yuh MORIMOTO, Tadashi BABA, Isao HAYAKAWA
Life of this patent
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Abstract
A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.
Claims12
A compound represented by the following general formula (I):
- wherein, in the formula, R1 represents a C1-C6 alkyl group which may have a substituent, a C1-C6 alkenyl group which may have a substituent, or an aryl group which may have a substituent, provided that R1 may bind with R6 to form a partially unsaturated or saturated heterocyclic ring containing one or two or more ring-constituting heteroatoms (the ring may have a substituent);
- R2 represents hydrogen atom, carboxyl group, or amino group;
- R3 represents hydroxy group, or a C1-C6 alkyl group which may have a substituent;
- R4 represents hydrogen atom, a halogen atom, a C1-C6 alkyl group which may have a substituent, or a C1-C6 alkoxy group which may have a substituent, provided that R4 may bind with R5 to form a partially unsaturated or saturated heterocyclic ring containing one or two or more ring-constituting heteroatoms (the ring may have a substituent);
- R5 represents a C1-C6 alkyl group which may have a substituent, a C1-C6 alkoxy group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, or a partially saturated or saturated heterocyclic group which may have a substituent, provided that R5 may bind with R6 to form a partially unsaturated or saturated heterocyclic ring containing one or two or more ring-constituting heteroatoms (the ring may have a substituent);
- and R6 represents hydrogen atom, a C1-C6 alkyl group which may have a substituent, a C1-C6 alkoxy group which may have a substituent, or a halogen atom, or a salt thereof.
3 more elements
Dependencies are inferred from the claim text.