Dual run cassette for the synthesis of 18f-labelled compounds
AssigneeGe Healthcare Limited
InventorXavier Franci
Life of this patent
Estimating the term…
Abstract
The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.
Claims41
A cassette for the synthesis of a plurality of batches of an [18F]-labelled positron-emission tomography (PET) tracer wherein said cassette comprises:
- (i) an anion exchange column for each of said plurality of batches;
- (ii) a reaction vessel;
- (iii) a vial containing an aliquot of eluent for each of said plurality of batches;
- (iv) a vial containing an aliquot of a precursor compound for each of said plurality of batches;
- (v) reagent vials wherein each reagent vial contains an aliquot of reagent for each of said plurality of batches;
- (vi) optionally, a solid-phase extraction (SPE) column for deprotection and/or one or more SPE columns for purification;
- and,
- (vii) means for cleaning said reaction vessel and said SPE columns.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method for the synthesis of a plurality of batches of an [18F]-labelled PET tracer wherein said method comprises:
- (a) trapping a first aliquot of [18F]fluoride onto a first anion exchange column;
- (b) providing a first aliquot of a precursor compound in a reaction vessel;
- (c) passing a first aliquot of eluent through said first anion exchange column to elute said first aliquot of [18F]fluoride into said reaction vessel;
- (d) heating the reaction vessel for a predetermined time to obtain crude [18F]-labelled labelled PET tracer;
- (e) optionally deprotecting said crude [18F]-labelled PET tracer on a SPE column;
- (f) optionally purifying said crude [18F]-labelled PET tracer on one or more SPE columns;
- (g) cleaning said reaction vessel and said SPE columns;
- (h) repeating steps (a)-(g) one or more times, each time using a subsequent aliquot of [18F]fluoride, a subsequent anion exchange column and a subsequent aliquot of a precursor compound;
- wherein said method is carried out on a single cassette.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.