Glucose regulation via electrical stimulation of nerves innervating the liver

A device for causing a perturbation of blood glucose level in a subject, comprising:

• a first electrode configured to attach to a portion of a hepatic branch of the subject's vagus nerve;
• a second electrode configured to attach to a portion of the subject's greater splanchnic nerve;
• a stimulus generator operably coupled with the first electrode and the second electrode, the stimulus generator being configured to provide stimulus signals to at least one of the first electrode and the second electrode;
• and
• a control unit operably coupled with the stimulus generator, the control unit comprising a processor and memory operably coupled to the processor, wherein the control unit is configured to control the stimulus generator to:
• provide a first stimulus signal configured to selectively excite neural activity of at least one of the hepatic branch of the subject's vagus nerve or the subject's greater splanchnic nerve;
• and
• provide a second stimulus signal having a frequency greater than about 5 kHz and configured to selectively inhibit neural activity of at least one of the hepatic branch of the subject's vagus nerve or the subject's greater splanchnic nerve, wherein the selective excitation and inhibition of neural activity causes the subject's blood glucose level to increase or decrease as compared to a baseline level.