Compressed bone composition and methods of use thereof
AssigneeLifeNet Health
InventorsMichael Francis, Rudy Rodriguez, Nathan Kemper
Life of this patent
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Abstract
The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.
Claims56
A method for preparing a compressed bone composition, comprising:
- loading bone particles into a mold with a predetermined shape,
- applying pressure between about 0.1 and 30 MPa to the bone particles, and
- freeze drying the compressed bone particles to create the compressed bone composition.
A bone composition comprising bone fibers, wherein the bone fibers comprise microfibers having an average width (W) of less than about 5 μm and an average length (L):W ratio of greater than about 2.
A method of making a bone implant for an individual, the method comprising:
- loading bone composition into a mold that is based upon three dimensional (3D) measurements taken from a bone structure of the individual for the implant, wherein the bone composition comprises microfibers having an average length (L):average width (W) ratio greater than about 2;
- applying pressure of between about 0.1 and 30 MPa to the bone composition to fit the mold;
- and
- freeze drying the compressed bone composition to make the bone implant.
A method of promoting osteoinductivity, osteoconductivity, chondroinductivity, chondroconductivity, or ligament/tendon differentiation or growth of cells, comprising contacting cells with a bone composition comprising bone fibers, wherein the bone fibers comprise microfibers having an average width (W) of less than about 5 μm and an average length (L):W ratio of greater than about 2.
Dependencies are inferred from the claim text.